NAD+ and Aging-Related Cellular Decline

Research shows that NAD+ levels decline with age, influencing cellular metabolism.

Imai, S., & Guarente, L. (2014)
"NAD⁺ and sirtuins in aging and disease"
📍 Trends in Cell Biology
🔗 https://pubmed.ncbi.nlm.nih.gov/24786309/

NAD+ and sirtuins in aging and disease

Shin-ichiro Imai 1, Leonard Guarente 2Affiliations expand

• PMID: 24786309
• PMCID: PMC4112140
• DOI: 10.1016/j.tcb.2014.04.002

Abstract

Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD(+) biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD(+) levels decline during the aging process and may be an Achilles' heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD(+) intermediate supplementation may be an effective antiaging intervention, providing hope to aging societies worldwide.

Keywords: NAD(+); nicotinamide mononucleotide; nicotinamide phosphoribosyltransferase; nicotinamide riboside; poly-ADP-ribose polymerases; sirtuins.

Copyright © 2014 Elsevier Ltd. All rights reserved.

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Figures

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Various uses of NAD + …

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NAD + biosynthetic pathways in…

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Synthesis of NAD + is…

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Electron transport via NADH generates…